Paragangliomas that are localized in the adrenal medulla are called pheochromocytomas (PHEOs; or more uncommonly termed adrenal medullary PGLs) (3). In the absence of universally established criteria for defining malignancy, a PHEO is considered to be malignant in the presence of metastases (4).

May 31, 2023 · Metaiodobenzylguanidine (MIBG) scintigraphy is the current gold standard functional imaging method for evaluating pheochromocytoma, due to its excellent 100% specificity, 80% sensitivity, and general availability.

An MIBG scan is a nuclear imaging test that helps healthcare providers diagnose and assess neuroendocrine tumors. Your provider injects a radioactive tracer, called iodine meta-iodobenzylguanidine (MIBG), into your bloodstream.

Correct and timely diagnosis of pheochromocytomas is crucial for patients' positive clinical outcome. The management and treatment of suspected pheochromocytomas usually starts with a biochemical investigation followed by morphological imaging, usually computed tomography (CT).

Aug 28, 2024 · I-123 MIBG uptake in an adrenal nodule is strong supporting evidence for a pheochromocytoma. Overall sensitivity is ~80% 6 . However, as many neuroendocrine tumors demonstrate uptake with MIBG , it is not as specific for pheochromocytoma outside of the adrenal.

Jul 29, 2024 · Catecholamine-secreting tumors that arise from chromaffin cells of the adrenal medulla and the sympathetic ganglia are referred to as "pheochromocytomas" and "catecholamine-secreting paragangliomas" ("extra-adrenal pheochromocytomas"), respectively.

Oct 21, 2024 · MIBG scan is a scintigraphic study that uses metaiodobenzylguanidine, norepinephrine analog 9, labeled to iodine-123 or iodine-131. It is indicated in the investigation of pheochromocytoma. I-131 MIBG, also called I-131 iobenguane, is a theranostic agent used to treat unresectable MIBG-positive tumors. Indications. MIBG is positive in ...

Metaiodobenzylguanidine, a guanithidine analog, labeled with 123 I and 131 I, is used for imaging and therapy of neuroblastomas and various neural crest tumors like paragangliomas, pheochromocytomas, medullary cancer of thyroid and carcinoids …

Jul 2, 2019 · MIBG is the most common and available imaging technique in the functional assessment of pheochromocytomas and has historically been the gold standard. MIBG is a structural and functional analog of norepinephrine and guanethidine.

Doctors have a number of options when they order scans or x-rays to look for the presence of a pheochromocytoma within the adrenal gland. These imaging choices include: Ultrasound, CT scans, MRI scans and Nuclear Medicine scans (MIBG, PET scans, etc).