eLife2d
Scrutinized lipid utilization disrupts Amphotericin-B responsiveness in clinical isolates of Leishmania donovani
The management of Leishmania donova ni (LD), responsible for fatal visceral leishmaniasis (VL), faces increasing challenges due to rising drug-unresponsiveness, leading to increasing treatment ...
Too Old to Operate5d
Bruton’s tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax.
Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. Though potentially curable with frontline ...
EurekAlert!10d
Schematic illustration of Z526's effects on cancer-associated cachexia. (IMAGE)
In cancer-associated cachexia, elevated TNF-α and IL-6 exacerbate muscle and fat loss by regulating multiple metabolic signaling pathways, which could be ameliorated by Z526's suppression of NF-κB ...
Joplin Globe16d
Verastem Oncology Outlines 2025 Strategic Priorities and Milestones for Novel Pipeline Targeting RAS/MAPK Pathway-Driven Cancers
Verastem Oncology (Nasdaq: VSTM), a biopharmaceutical company committed to advancing new medicines for patients with RAS/MAPK pathway-driven cancers, today announced its 2025 priorities and upcoming ...
West Ham United F.C.18d
Academy trio inspire the next generation at Player Pathway session
Participants from the West Ham United Foundation’s Player Pathway programme were recently surprised by a visit from Academy players Ollie Scarles, Kaelan Casey and Fin Herrick. Boys from the U12s, ...
New York Post24d
The 16 best nutritionist-backed protein bars we tested for every diet
But FULFIL bars aren’t just stacked with 15 grams of protein, they’re also packed with vitamins A, B6, B12, C, and E to give you all the energy you need to get swinging. NY Post review ...
Ars Technica24d
Researchers use AI to design proteins that block snake venom toxins
It has been a few years since AI began successfully tackling the challenge of predicting the three-dimensional structure of proteins, complex molecules that are essential for all life. Next ...
Windtree Strengthens Global Intellectual Property Portfolio with New Japanese Patent For the Company’s Oncology Pipeline
Detailed price information for Windtree Therapeutics Inc (WINT-Q) from The Globe and Mail including charting and trades.
Phys.org24d
Artificial motors mimic muscle proteins, opening new paths in nanotech
Just like the proteins in our muscles, which convert chemical energy into power to allow us to perform daily tasks, these tiny rotary motors use chemical energy to generate force, store energy ...
The EMBO Journal24d
A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease
Knock-down of the E3 ligase ITCH in fdAT2 organoids phenocopies a pathological surfactant protein C trafficking defect seen in a subset of individuals with familial pulmonary fibrosis. Our data ...
Phys.org25d
Novel pathway shows how blue light damages cellular proteins by bypassing antioxidant defense systems
A research team from the Department of Chemistry at UNIST has announced that they have identified a novel pathway through which blue light can damage cellular proteins. Blue light, which emanates ...