Hyperpathia, hyperalgesia, and allodynia are three manifestations of central sensitization, a condition in which a higher than necessary degree of activity is triggered in the central nervous system.

9 Central sensitisation can be seen as an umbrella term,9 the main characteristics of which are: Hyperalgesia is an increased pain response to normally painful stimuli and may be as a result of ...

"Understanding the mechanisms underlying tolerance and hyperalgesia is essential to enhance morphine's utility in chronic ...

In the periphery, TRPV1 is activated by exposure to noxious heat and protons and is responsible for peripheral heat hyperalgesia. Central sensitization is a major problem in pain conditions across ...

Research reveals that δ-receptor agonists like KNT-127 alleviate IBS symptoms by modulating gut-brain interactions and ...

Preclinical data previously published in the peer-reviewed journal, The Journal of Pain, 1 demonstrate robust antinociceptive effects of AV-101, similar to gabapentin, but with a better side effect ...