Australian cancer researchers are the first to establish a next-generation gene-editing tool for modeling and interrogating human disease.

High CDC20 expression promotes aneuploid cancer cell sensitivity to spindle assembly checkpoint (SAC) inhibition by ...

The paper presents a streamlined new approach for functional validation of genes known to underlie fragile bone disorders in a relatively high throughput, using CRISPR-mediated knockouts ... of ...

CRISPR Therapeutics' stock decline is likely influenced by Editas Medicine's struggles, but CRISPR remains a distinct and stronger company with a promising long-term outlook. CRISPR's strategic ...

Efficiency: Advances in sgRNA design and delivery systems ensure higher success rates in genome-wide studies. These benefits make CRISPR libraries an essential tool in both academic and industrial ...

CRISPR-Cas9 is one of the biggest discoveries of the 21st century. Since it was developed in 2012, this gene-editing tool has revolutionized biology research, making it easier to study disease and ...

Screening is the only way to know if your cholesterol level is abnormal. Cholesterol is a waxy substance found in the body's tissues. The body produces cholesterol and also receives it from food.

Get Instant Summarized Text (Gist) CRISPR nucleases, Cas9 and Cas12, have been engineered to evade immune detection, addressing a key challenge in CRISPR-based therapies. By identifying and ...

Bring up germline editing, and most scientists cringe. The idea behind the notorious CRISPR-baby scandal, editing reproductive cells or embryos tinkers with DNA far beyond just the patient—any changes ...

Here, we introduce CRISPR-Enabled Autonomous Transposable Element (CREATE ... Next, we investigated the impact of the off-set distance between the two sgRNA target sites on editing efficiency. Three ...