CRISPR technology has radically transformed genetic research, and at the forefront of this transformation is CRISPR screening ...

This study presents an optimized CRISPR-Cas12a system for large-scale genetic screening, revealing critical genes involved in ...

The platform enables direct, unbiased genome-wide identification and quantification of the exact position of double strand ...

Treatment for sickle cell disease, the most common inherited blood disorder in Kenya, has been approved for use in England for older children and adults with a severe form of the disease.The treatment ...

A research team has made a major discovery on how the CUL5 gene affects CAR-T cell therapy, an advanced cancer therapy. The study reveals that reducing the activity of the CUL5 gene helps CAR-T cells ...

Researchers have identified a method to enhance the effectiveness of a promising cancer treatment. They found that modifying ...

Researchers determined the clinical classification of more than 90% of potential BRCA2 variants of uncertain significance in ...

Precision medicine is an innovative approach in healthcare that takes into account individual differences in genes, ...

expanding CRISPRi targeting scope for functional genomics and enabling efficient screening of repeated genomic elements Type I-E CRISPR–Cas system is one of the most extensively studied RNA ...