Northwestern Medicine investigators have developed a new avenue to reprogram compromised immune cells to act against tumors, ...

CRISPR technology has radically transformed genetic research, and at the forefront of this transformation is CRISPR screening ...

A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...

Northwestern Medicine scientists have uncovered new details explaining how poxviruses manipulate host cells to enhance their own protein production, according to a study published in Cell Reports.

Scientists from the Cancer Dependency Map (DepMap) at the Broad Institute of MIT and Harvard and Columbia University have ...

It’s a new way to create “bi-paternal” mice that can survive to adulthood—but human applications are still a long way off.

Synthego, a leading genome engineering solutions company, today announced the launch of the Gene Knockout Kit v2. This is the only product that leverages a novel bioinformatics- powered multi-guide ...

With CRISPR, researchers routinely knock out gene function by cutting out a DNA fragment, or they insert a desired genetic sequence into the genome by providing a reference DNA template along with the ...

CRISPR stocks are high risk but hold potential for aggressive investors. CRISPR Therapeutics and its partner Vertex Pharmaceuticals have the only approved CRISPR therapy. Several other biotech ...

Additionally, the authors create whole-genome Cas12a knockout libraries, and demonstrate their utility across multiple in vitro and in vivo screens. CRISPR-based detection has long been challenged ...

Australian researchers have successfully introduced an improved version of Cas12a gene-editing enzyme in mice.