The most complex engineering of human cell lines ever has been achieved by scientists, revealing that our genomes are more resilient to significant structural changes than was previously thought.

NanoCas, an ultracompact nuclease, enables efficient muscle editing in NHPs using a single AAV - advancing gene editing for hard-to-target tissues.

Visualizing cells after editing specific genes can help scientists learn new details about the function of those genes. But ...

The paper presents a streamlined new approach for functional validation of genes known to underlie fragile bone disorders in a relatively high throughput, using CRISPR-mediated knockouts ... of ...

CRISPR Therapeutics' stock decline is likely influenced by Editas Medicine's struggles, but CRISPR remains a distinct and stronger company with a promising long-term outlook. CRISPR's strategic ...

CRISPR screening libraries are collections of carefully designed single-guide RNAs (sgRNAs) that allow researchers to systematically manipulate thousands of genes simultaneously. This high-throughput ...

And death rates are on course to rise by a third this year – an alarming reminder to take up any offers of bowel cancer screening and treat any symptoms seriously. Yet having bowel cancer isn ...

Screening is the only way to know if your cholesterol level is abnormal. Cholesterol is a waxy substance found in the body's tissues. The body produces cholesterol and also receives it from food.

Get Instant Summarized Text (Gist) CRISPR nucleases, Cas9 and Cas12, have been engineered to evade immune detection, addressing a key challenge in CRISPR-based therapies. By identifying and ...

Here, we introduce CRISPR-Enabled Autonomous Transposable Element (CREATE), a genome editing system that combines the programmability and precision of CRISPR/Cas9 with the RNA-mediated gene insertion ...