“The exact mechanism of action of D13 is not fully understood yet but ... some first and second generation compounds also demonstrated excellent antifungal activity at very low drug concentrations, ...

An often-overlooked mechanism of gene regulation may be involved in the failure of antifungal drugs in the clinic ... used the known mode of action of fluorocytosine on A. fumigatus as the basis for ...

The FAILSAFE project (Fungal AMR Innovations for LMICS: Solutions and Access For Everyone) is a groundbreaking initiative tackling antifungal drug resistance. The project aims to promote worldwide ...

A recent survey reveals a significant decline in teen drug and alcohol use since 2017, reaching its lowest point in 2024. Researchers attribute this drop to pandemic lockdowns disrupting social ...

See the article: Improving the production of micafungin precursor FR901379 in Coleophoma empetri using heavy-ion irradiation and its mechanism analysis ...

One thing is certain: The threat of fungal infections is growing, as fungi either evolve ways to evade drugs that once worked, or pop up in places they haven’t been seen before. “We have limited ...

2020). Therefore, there is a pressing need for the development of green fungicides with a new type of molecular scaffolds or new action mechanisms appears urgent necessary. Intermediate 4 was ...

FIGURE 1. Possible inhibitory effects of phytochemicals on the cell signaling pathways (MAPKs, PI3K/Akt, NF-κB, and Wnt). The blocking of target proteins in the signal pathways by the compounds is ...

The experience and recommendations of combinational antifungal therapy for cryptococcal ... giving some information on mechanism of action and principles in combined use of mycotic anti-infectives.