The cyclic AMP/protein kinase A (cAMP/PKA) pathway is one of the most common and versatile signal pathways in eukaryotic cells. A-kinase anchoring proteins (AKAPs) target PKA to specific substrates ...

Figure 2. Crosstalk between the GPCR and JAK2-STAT5 signaling pathways. AC, adenylyl cyclase; cAMP, cellular adenosine 3’,5’-cyclic monophosphate; GPCR, G protein-coupled receptor; JAK2, Janus kinase ...

A new study shows how an anticancer drug triggers an 'outside in' signal that gets it sucked into a cancer cell. The work reveals a new signaling mechanism that could be exploited for delivering other ...

The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study. Blocking ...

A new study shows how an anticancer drug triggers an "outside in" signal that gets it sucked into a cancer cell. The work, ...

7 refine our understanding of the signaling effects of oncogenic KRAS. Rather than activating multiple effectors, mutant KRAS signals preferentially through the RAF–MEK–ERK pathway ...

This valuable study presents a mouse gastruloid model that can be used to generate hematopoietic progenitors as well as leukemic cells. However, in its current form, the manuscript is inadequate ...

The articles in this special issue highlight the diversity and complexity of research into reproductive health, including the need for a better understanding of the fundamental biology of reproduction ...

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Rather, it could be due to a poor connection to the network. That's why the best cell phone signal boosters help boost your cell reception in your home, office, or car. The last thing you need to ...