She had worsening anemia, but thrombotic thrombocytopenic purpura was ruled out, as there was no conclusive evidence of microangiopathic hemolytic anemia. CT of the brain revealed multiple ...

Rituximab, a monoclonal antibody directed against the CD20 molecule found on pre-B cells and mature B cells (but not on plasma cells), was introduced in the late 1990s for the treatment of non ...

Here, we discuss the recent advances describing the molecular and structural basis of activation and regulation of the complement pathways and their implication on physiology and pathology. This ...

such as thrombotic microangiopathies (TMAs), thrombotic thrombocytopenic purpura/hemolytic uremic syndromes (TTP/HUS), and disseminated intravascular coagulation (DIC). TAMOF manifests as a sudden ...