Scientists create method for designing proteins that can bind and sense a range of small molecules
From growth hormones to cancer drugs, small molecules play a crucial role in our health. Monitoring them is essential to ...
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New algorithm for functional protein design outperforms traditional methods
efficiently generates protein pocket sequences and spatial structures for binding small molecules. The study was published in Nature Machine Intelligence. Functional protein design, particularly ...
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Efficient generation of protein pockets with PocketGen (IMAGE)
(a) Protein sequence-structure co-design with PocketGen; (b) Dual-layer graph Transformer encoder; (c) Pre-trained protein language model for sequence prediction and efficient fine-tuning.