A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...

CRISPR technology has radically transformed genetic research, and at the forefront of this transformation is CRISPR screening ...

Biomedical engineers at Duke University have demonstrated a promising new approach that could be used to treat a rare and complex class of genetic ...

Centrosomes are nonmembrane organelles and responsible for microtubule nucleation and organization. Centrosomal RNAs have been identified in diverse model systems and are known to regulate gene ...

The CRISPR-Cas9 platform will be used to delete the ... effectively preventing immune cells killing them. The same mechanism has been identified as a potential survival pathway for cancer cells ...

Understanding stress physiology and molecular response mechanisms in plants is essential for improving crop production and quality, particularly under ...

This study presents an optimized CRISPR-Cas12a system for large-scale genetic screening, revealing critical genes involved in ...

Originally discovered in bacteria as a defense mechanism against pathogens ... contributed significantly to the deciphering of the CRISPR-Cas9 mechanism in bacteria and my colleagues of the ...

Beans are a key food at the dietary level, boasting high nutritional value and constituting the most directly consumed legume ...

Protein synthesis is vital for life, translating genetic information from DNA to functional proteins through transcription ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

CRISPR-Cas systems are prokaryotic immune systems ... when delivered with adeno-associated viral gene therapy. SeqCas9, a Cas9 variant from the Streptococcus family, recognizes a simple NNG ...