San Francisco 49ers left tackle Trent Williams gives a clear analysis of the team's injuries and talked about the ...

Injuries already are accruing across the NFL, knocking several star players out and forcing teams to turn to backups and ...

Matthew Berry breaks down his Love/Hate players for Week 3 and explains to fantasy managers why their seasons aren't over despite dealing with a rash of injuries.

The 49ers woes in Minnesota continued last week when their former quarterback Sam Darnold torched his old squad. The offense ...

After a 23-17 upset loss to the Minnesota Vikings in Week 2, the 49ers are 1-1 on the year and are officially vulnerable to ...

The San Francisco 49ers will be without the services of one of their top offensive weapons for the foreseeable future.

Alvin Kamara surpassed Christian McCaffrey in career touchdowns scored, ranking sixth-best among active players. Klint Kubiak ...

NFL Week 3 odds, picks, predictions, TV and streaming information for the Sunday football game between the San Francisco ...

"He was the Offensive Player of the Year for a reason," tight end George Kittle said. "He was in the MVP voting for a reason.

49ers coach Kyle Shanahan said the timeline for running back Christian McCaffrey’s return is unknown.

Now, NFL Network insider Ian Rapoport has unveiled a likely worst-case timeline for McCaffrey to return to game action.

The San Francisco 49ers already placed Christian McCaffrey on Injured Reserve and that means he cannot return at least in ...