The intravenously-administered cephalosporin drug met its objectives ... ceftobiprole but that was expected given the drug's mechanism of action. Ceftobiprole has qualified infectious disease ...

Of the 13 late-stage projects, just three had an entirely new mechanism of action which should avoid resistance, namely GSK’s gepotidacin (GSK2140944), Summit Therapeutics’ ridinilazole ...

In fact, most current antibiotics are derived from a mere 15 or so base compounds, the main ones being the β-lactams (e.g., penicillins, methicillin, and cephalosporin), aminoglycosides (e.g ...

is an advanced siderophore cephalosporin antibiotic approved for the treatment of complicated urinary tract infections (cUTIs), including those caused by multidrug-resistant Gram-negative pathogens.

ESBLs are a family of enzymes conferring resistance to β-lactam antibiotics, such as penicillins, cephalosporins ... documented to be transmitted from one organism to another through mechanisms of ...

Many authors have suggested using a cephalosporin as an alternative to penicillin. Casey and Pichichero performed a meta-analysis of 35 randomized, controlled trials comparing penicillin with ...

Herein, we review the evolution, origin and spread of antimicrobial resistance and resistance determinants (with a focus on extended-spectrum cephalosporins) in N. gonorrhoeae, detail the current ...

The SARS-CoV-2 pandemic interrupted much respiratory research. Respiratory clinical academics joined colleagues in providing clinical care, and global research efforts were directed to finding new ...

First generation cephalosporins (Cefadroxil, Cefalexin, Cefazolin, and Cefradine) can now be used as first line treatments in the UK after an update from the UK Health Security Agency (UKHSA).1 The ...

Mechanism of action describes the process by which a molecule, such as a drug, functions to produce a pharmacological effect. A drug’s mechanism of action may refer to its effects on a ...

Even though there are indications of the health-promoting and cell-protective properties of ergothioneine, the underlying mechanism of action was previously unknown. "Our analyses now finally ...

2025 has a full slate of action movies, each more exciting than the next. The genre has never been more popular, and luckily for audiences, creatives and producers know it. Action is also ...