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As an intrinsic cellular pathway, nonsense- mediated decay (NMD) conceals neoantigens through the destruction of the RNA products from genes harboring truncating mutations. We developed and conducted ...

elegans, mice or fish. ‘To understand the mechanism, it is important to know that in DMD, various mutations in the dystrophin gene prevent the production of a functional gene product, i.e. a protein.

The deletion of residues 239-272 from the hamster beta-adrenergic receptor resulted in a loss of the ability of the receptor, expressed in mouse L cells, to stimulate adenylate cyclase (Dixon, R. A. F ...

The primer set (forward: 5’-GAG AGC ACC GAG CCC CTG AGT GAG G-3’ and reverse: 5’-CAC CAT GGG CAG GTC CAT GTT GAT G-3’) was used to amplify the region containing the mutation site. The PCR product was ...

Our current knowledge is not enough advanced to explain the mechanisms involved in APA formation. However, the identification, in about 50% of APA, of recurrent somatic mutations in genes coding for ...