Can we predict that natural selection will weed out genetic disease over time? Sickle-cell trait haplotype distribution shows the genetic advantages of this mutation. In the deoxygenated ...

The UAB Comprehensive Sickle Cell Center brings together scholars and researchers working in the forefront of basic, translational and clinical research, with the overarching goals to discover new ...

Sickle cell disease is a group of inherited red blood cell disorders ... A vector is part of a virus. Kanter compares vectors to envelopes and letters. “I like to think of it [the viral vector] as an ...

Individuals with sickle cell disease – a chronic illness where misshapen, sticky blood cells clump together, reducing oxygen ...

In particular, the HGB-205 trial demonstrated the long-term benefits of lentiviral gene therapy for β-hemoglobinopathies, such as sickle ... healthy stem cells. Lentiviral Vectors (LV): A type ...