It feels like Bloodborne was designed with this style of play in mind. After defeating Rom, the Vacuous Spider, I was unsure of the best direction to go in next. I wandered the Yahar'gul Chapel ...

The one note that stuck around was a note referencing Rom, The Vacuous Spider. While this isn't explored in the video, it's also theorized that this is why there's a big chest next to the door ...