Using a single short RNA, such as a CRISPR guide RNA, to manipulate transcriptional activity at multiple copies of an element should work in theory, says Wysocka. But in practice, “because over ...

Cell 171, 414-426. Initial step of DNA integration by a CRISPR-Cas transposon complex. Bioinformatic analysis has revealed the presence of CRISPR-Cas loci in bacterial Tn7-like transposons, thereby ...

Efficient and site-specific genome engineering can be achieved based on programmable nucleic acid cleavage using CRISPR-Cas surveillance complexes. Structure-function studies on single component Cas ...

Horizon develops genetically engineered cell models using its suite of DNA editing tools (rAAV, ZFN, CRISPR and Transposon). From this, Horizon offers a range of products and services that enable ...

Sahana is a science journalist and an intern at The Scientist, with a background in neuroscience and microbiology. She has previously written for Live Science, Massive Science, and eLife. View Full ...

“The functional genomics field has gone through several waves of evolution, starting with circulating DNA expression screens, RNA interference (RNAi), transposon/retroviral insertion screening and the ...

CRISPR is a technology that can be used to edit genes and, as such, will likely change the world. The essence of CRISPR is simple: it’s a way of finding a specific bit of DNA inside a cell.