Using a single short RNA, such as a CRISPR guide RNA, to manipulate transcriptional activity at multiple copies of an element should work in theory, says Wysocka. But in practice, “because over ...

CRISPR is a technology that can be used to edit genes and, as such, will likely change the world. The essence of CRISPR is simple: it’s a way of finding a specific bit of DNA inside a cell.

Sahana is a science journalist and an intern at The Scientist, with a background in neuroscience and microbiology. She has previously written for Live Science, Massive Science, and eLife. View Full ...

Efficient and site-specific genome engineering can be achieved based on programmable nucleic acid cleavage using CRISPR-Cas surveillance complexes. Structure-function studies on single component Cas ...

Horizon develops genetically engineered cell models using its suite of DNA editing tools (rAAV, ZFN, CRISPR and Transposon). From this, Horizon offers a range of products and services that enable ...

Cell 171, 414-426. Initial step of DNA integration by a CRISPR-Cas transposon complex. Bioinformatic analysis has revealed the presence of CRISPR-Cas loci in bacterial Tn7-like transposons, thereby ...

“The functional genomics field has gone through several waves of evolution, starting with circulating DNA expression screens, RNA interference (RNAi), transposon/retroviral insertion screening and the ...

CRISPR Therapeutics' stock decline is likely influenced by Editas Medicine's struggles, but CRISPR remains a distinct and stronger company with a promising long-term outlook. CRISPR's strategic ...

Shares of CRISPR Therapeutics CRSP have lost more than 30% in the past year. Though the stock soared at the onset of 2024, thanks to the FDA approval of its one-shot gene therapy Casgevy for two ...