How a natural compound from sea squirts combats cancer
TC-NER is a vital mechanism that identifies DNA damage during transcription, initiating repair processes involving two ...
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Figure 3 (IMAGE)
Summary of the mechanism of trabectedin-induced TC-NER-mediated break formation and break mapping by TRABI-Seq. Trabectedin-DNA adducts are recognized by TC-NER and lead to an abortive reaction as ...
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Figure 2 (IMAGE)
The breaks are dependent on NER as they do not occur in TC-NER deficient cells (right) with inactivated XPF gene.