In the periphery, TRPV1 is activated by exposure to noxious heat and protons and is responsible for peripheral heat hyperalgesia. Central sensitization is a major problem in pain conditions across ...

According to published results, a novel opioid-free pathway may provide noninferior pain management compared with an opioid-containing pathway during the perioperative period in patients undergoing ...

A common genetic pathway may account for increased risk for atherosclerotic disease in patients with chronic widespread musculoskeletal pain.

In Brazil, researchers have identified substances with analgesic, anti-inflammatory, anti-hyperalgesic (against persistent pain ... and mechanical hyperalgesia (increased sensitivity to painful ...

Systemic inhibition of interleukin (IL)-1 with rilonacept (IL-1 Trap) could be an effective therapy for the pain and inflammation ... ankle joint synovitis and hyperalgesia induced by monosodium ...