When choosing an opioid, the World Health Organization recommends using a systematic and graduated approach, the "analgaesic ladder," starting with non-narcotics, then changing to weak opioids and ...

the drug would be placed in the third tier of the WHO analgesic ladder, at the same level as potent opioids; but due to its side effect profile, it could be placed in the second tier, along with ...

In 1986, the World Health Organization released the Pain Relief Ladder (Figure 1). [3] The principle is that the lowest effective dose of an opioid should be used to minimize the impact of its ...