"Understanding the mechanisms underlying tolerance and hyperalgesia is essential to enhance morphine's utility in chronic ...

Research reveals that δ-receptor agonists like KNT-127 alleviate IBS symptoms by modulating gut-brain interactions and ...

Opioid-induced hyperalgesia (OIH) and allodynia; consider decreasing dose of current opioid or opioid rotation if OIH is suspected. COPD, cor pulmonale, decreased respiratory reserve, hypoxia ...

may be an appropriate response to inadequately treated pain Opioid-induced hyperalgesia A neuroplastic change in pain perception resulting in an increase in pain sensitivity to painful stimuli ...

Opioid addicts exhibit short tolerance to the cold pressor test, as manifested by their quicker hand withdrawal, which can be interpreted as hyperalgesia. A growing number of animal and human ...

Opioid-induced hyperalgesia (OIH) and allodynia; consider decreasing dose of current opioid or opioid rotation if OIH is suspected. COPD, cor pulmonale, decreased respiratory reserve, hypoxia ...

“This is a really fascinating separation of the pharmacology [of morphine],” said Mark Hutchinson, biological pharmacologist at the University of Adelaide who was not involved with the study. To test ...