They cited a pharmacokinetic study suggesting that a daily metformin dose of 500 mg appears safe in stage 4 CKD, but cautioned that follow-up was short. Dr Bell’s team summarized that ...

Metformin is taken at doses of 500 milligrams (mg) to 2550 mg a day. Your healthcare provider will start your prescription at a low dose and gradually increase it according to your body’s needs.