Circulating insulin binds to insulin receptors on blood vessel endothelium, leading to activation of endothelial nitric oxide synthase (eNOS), NO-mediated vasodilation and increased perfusion of ...
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High levels of adrenomedullin found to promote obesity-associated insulin resistancereducing insulin receptor signaling within endothelial cells. High-resolution phosphoproteomic screens pinpointed serine 205 in PTP1B as the principal site phosphorylated by PKA. Mutating this ...
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