Proteins have four levels of structure: primary (amino acid sequence), secondary (local folding patterns like alpha helices and beta sheets), tertiary (overall 3D shape), and quaternary (assembly of ...

The shape of a protein determines what it can interact with, just like the shape of a key determines which locks it can operate. Most of the proteins in your body can be grouped into four ...

Today, however, most cryo-EM studies resolve protein structures only to about three or four angstroms, leaving a picture that’s too blurry for structure-based drug design. And despite AlphaFold ...

While discovering that DNA is itself a long polymer made out of four ... sheet structure and the aggregation of these altered proteins; thus they seem fundamental to the prevention of protein ...