Proteins have four levels of structure: primary (amino acid sequence), secondary (local folding patterns like alpha helices and beta sheets), tertiary (overall 3D shape), and quaternary (assembly of ...

In fact, each gene in cellular DNA contains the code for a unique protein structure. Not only are these proteins assembled with different amino acid sequences, but they also are held together by ...

Today, however, most cryo-EM studies resolve protein structures only to about three or four angstroms, leaving a picture that’s too blurry for structure-based drug design. And despite AlphaFold ...

The shape of a protein determines what it can interact with, just like the shape of a key determines which locks it can operate. Most of the proteins in your body can be grouped into four ...