DNA integrity is always under attack from environmental agents like skin cancer-causing UV rays. How do DNA repair mechanisms ... Thus, these two types of UV radiation are of greatest concern ...

DSBs can be repaired using several different ... DNA (light blue) can then be joined with the 5' end of the resected strand, forming a double Holliday junction (double-strand break repair; DSBR ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms ... attempts to copy the damaged DNA it can make a different mistake, leading to multiple different ...

In a groundbreaking shift in our understanding of mutations, researchers have discovered types of DNA damage in healthy cells ...

Scientists at Children's Medical Research Institute (CMRI) have solved a big mystery in cancer research—why cells die in different ways ... our research is that DNA repair, which normally ...

To maintain the integrity of the genetic information, cells have evolved various DNA repair mechanisms. These mechanisms can detect and correct different types of DNA damage, such as base mismatches, ...

The genetic connections between DNA repair pathways and human cancer predisposition have ... Yet the topology of the LigA clamp is starkly different from the clamps formed by ChVLig and human DNA ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms ... attempts to copy the damaged DNA it can make a different mistake, leading to multiple different ...

Northwestern Medicine investigators have discovered new molecular mechanisms underlying DNA repair dysregulation ... have been approved by FDA in different cancer types, including breast cancer ...

CRC Drug-DNA Interactions Research Group ... but many of the details are strikingly different, and it is likely that a novel excision repair reaction has been found. Figure 4 Model based on that ...