Molecules that combine elements of RNA and DNA, so-called chimeric molecules, may have been an important step in the emergence of life on Earth from the primordial soup that existed billions of years ...

Chimeric RNAs and the proteins translated from them often have a causal role in tumorigenesis. They are also occasionally found at low levels in healthy cells. These phenomena were previously ...

The ChiTaRS 8.0 database contains over 47,000 RNA transcripts and more than 100,000 chimeric sequences identified in humans. The database integrates with a "digital hospital" model, which allows ...

Transcription-induced RNA mutations include chimeric RNA, alternative splicing, alternative polyadenylation, and RNA editing. The prevalence of RNA mutations may allow the limited number of human ...

Chromosomal translocations resulting in gene fusions produce tumor-specific molecules because the chimeric RNA and protein product only occurs in the cell with the chromosomal translocation.

We recently demonstrated that an RNA-DNA oligonucleotide corrected a ... melanocytes from tissue culture to live animals, using a chimeric oligonucleotide designed to correct a point mutation ...

Zhang H, W. Lin, K. Kannan, L. Luo, J. Li, P-W Chao, Y. Wang, Y-P Chen, J. Gu, and L. Yen. Aberrant chimeric RNA GOLM1-MAK10 encoding a secreted fusion protein as a molecular signature for human ...