Complementary discoveries have the potential to enhance treatment options for antibiotic-resistant infections. Researchers at ...

CRISPR-Cas systems are prokaryotic immune systems that ... unintended large insertions using various donor types across multiple gene loci reveals widespread integration of genomic repetitive ...

Yet others, called base editors, change one letter of the DNA code to another. So why do we call it CRISPR? Cas proteins are used by bacteria to destroy viral DNA. They add bits of viral DNA to ...

All DNA-binding CRISPR-Cas systems use this structure to probe the ... Čepaitė et al, Structural variation of types IV-A1- and IV-A3-mediated CRISPR interference, Nature Communications (2024).

J. (2019a). Type III-A CRISPR Csm complexes: Assembly, target RNA recognition, periodic cleavage and autoimmunity. Mol. Cell 73, 264-267. CRISPR-Transposition Systems. Recent bioinformatics analyses ...

Over the years, scientists have explored alternatives to Cas9, such as Cas12a for more precise multigene editing, a type III CRISPR for ... Base and Prime Editing Offer Precision CRISPR-based systems ...

4 “Our motivation for this work was to unlock other possibilities for RNA editing,” said Nemudryi; he was searching for a system that could substitute or remove chunks of nucleic acids in the viral ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted ... unintended large insertions using various donor types across multiple gene loci reveals widespread ...

The epigenetic state of chromatin, gene activity, and chromosomal positions are interrelated. A research team from the IPK Leibniz Institute (IPK) and the Karlsruhe Institute of Technology (KIT) ...

The core components of CRISPR-based genome-editing ... parts of the nucleases the immune system recognized. To find out, Zhang's team used a specialized type of mass spectrometry to identify ...

Results prove that inversions can be generated in plants without causing further unwanted changes in the expression of genetic information.