Researchers have been working to find CRISPR/Cas nucleases with greater specificity ... related to hydrogen bonding with target DNA-sgRNA. The GFP reporting system was then used to test the ...

Cell Biol. 22, 563-579. Our group has determined the crystal structure of the complex formed by anti-CRISPR protein AcrIIA4 and sgRNA-bound type II Cas9. We show that AcrIIA4 preferentially targets ...

ZUG, Switzerland and BOSTON, Jan. 13, 2025 (GLOBE NEWSWIRE) -- CRISPR Therapeutics (Nasdaq: CRSP), a biopharmaceutical company focused on creating transformative gene-based medicines for serious ...

CRISPR is a technology that can be used to edit genes and, as such, will likely change the world. The essence of CRISPR is simple: it’s a way of finding a specific bit of DNA inside a cell.

Then Crispr came along—the elegant enzymatic apparatus that allows delivery of DNA scissors to a specific target in the genome. In December 2023, the FDA approved the first Crispr-based therapy ...

With a multidisciplinary team in his laboratory at the University of California, San Diego, he now develops tools through genetic engineering techniques such as CRISPR to solve the world’s insect ...