A study finds that CRISPR-Nickase, which changes just one allele of a given gene, improves gene editing efficiency compared with CRISPR-Cas9. A new method has allowed researchers to conduct the first ...

Get Instant Summarized Text (Gist) CRISPR nucleases, Cas9 and Cas12, have been engineered to evade immune detection, addressing a key challenge in CRISPR-based therapies. By identifying and ...

A CRISPR Cas9 nickase protein makes a single-strand DNA nick, and then a base-converting enzyme, physically attached to Cas9, makes a cytosine-to-thymine switch. We typically deliver base editors ...

CRISPR is a technology that can be used to edit genes and, as such, will likely change the world. The essence of CRISPR is simple: it’s a way of finding a specific bit of DNA inside a cell.