CRISPR interference (CRISPRi) is a novel method for specific gene knockdown. It's CRISPR, without the cut. The Horizon CRISPRi system uses a deactivated Cas9 nuclease (dCas9) fused to our proprietary ...

Čepaitė et al, Structural variation of types IV-A1- and IV-A3-mediated CRISPR interference, Nature Communications (2024). DOI: 10.1038/s41467-024-53778-1 Provided by Vilnius University ...

We use CRISPR-interference (also known as CRISPRi) instead of regular CRISPR because this technique does not cut DNA, but instead reduces the expression of a gene. If we consider regular CRISPR as ...

CRISPR Therapeutics' stock decline is likely influenced by Editas Medicine's struggles, but CRISPR remains a distinct and stronger company with a promising long-term outlook. CRISPR's strategic ...

This new tool, known as minimal, versatile genetic perturbation technology (mvGPT), combines the powers of gene editing, ...

Bring up germline editing, and most scientists cringe. The idea behind the notorious CRISPR-baby scandal, editing reproductive cells or embryos tinkers with DNA far beyond just the patient—any changes ...

The second tool is the CRISPR-Cas9 system, which allows easy and precise editing of any region of the genome. When it comes to traditional immortalized cell lines, such as HeLa or HEK293, cutting with ...

Before CRISPR, another gene-editing technique dominated. RNA interference (RNAi) revolutionized gene function experiments by allowing scientists to use small pieces of RNA to shut down the ...

CRISPR is a technology that can be used to edit genes and, as such, will likely change the world. The essence of CRISPR is simple: it’s a way of finding a specific bit of DNA inside a cell.