The CRISPR-Cascade assay achieves attomolar sensitivity and incorporates an OR-gated logic function to identify multiple pathogens simultaneously through DNA from pathogens associated with bloodstream ...

A new study presents a CRISPR-Cascade assay that eliminates this need, enabling highly sensitive, multiplexed detection of ...

More information: Jongwon Lim et al, Amplification-free, OR-gated CRISPR-Cascade reaction for pathogen detection in blood samples, Proceedings of the National Academy of Sciences (2025). DOI: 10. ...

Bashir's team created a CRISPR-based diagnostic test that bypasses that amplification step by combining two CRISPR/Cas units in a complex called CRISPR-Cascade. One unit contains a guide RNA ...

CRISPR is a technology that can be used to edit genes and, as such, will likely change the world. The essence of CRISPR is simple: it’s a way of finding a specific bit of DNA inside a cell.

Learn about our Editorial Policies. We can target harmful bacteria. We can engineer beneficial bacteria. We can use CRISPR to study microbial interactions. We can use CRISPR to remove antibiotic ...

Bioengineering professor and The Grainger College of Engineering’s Dean, Rashid Bashir, led a team of researchers in a project that’s resulted in new technology that offers rapid, highly ...