Australian cancer researchers are the first to establish a next-generation gene-editing tool for modeling and interrogating human disease.

Together, the technologies have fostered numerous advances in basic molecular and cell biology ... who received a Nobel Prize for the discovery of CRISPR-Cas9, along with her team at the ...

Here, Dr Jamie Freeman discusses how Horizon Discovery engineers cell lines to enable deeper understanding of basic biology of ... including CRISPR-Cas9 and ZFNs, and we have even developed ...

"This has important implications for basic research ... in the Chagas Disease Vector Rhodnius prolixus by Cas9-Mediated ReMOT Control, The CRISPR Journal (2024). DOI: 10.1089/crispr.

Among the most exciting breakthroughs are gene therapy and gene editing, with CRISPR-Cas9 leading the charge. This remarkable tool, inspired by bacteria's natural defenses, acts like precise ...

Our group has determined the crystal structure of the complex formed by anti-CRISPR protein AcrIIA4 and sgRNA-bound type II Cas9. We show that AcrIIA4 preferentially ... defines how a lysine-rich ...

Using CRISPR/Cas9-activation screen, functional analysis, and engineered zebrafish models, the study aims to uncover the mechanisms by which CRX and OTX2 regulate the retinoic acid signaling pathway ...