Australian cancer researchers are the first to establish a next-generation gene-editing tool for modeling and interrogating human disease.

Together, the technologies have fostered numerous advances in basic molecular and cell biology ... who received a Nobel Prize for the discovery of CRISPR-Cas9, along with her team at the ...

Here, Dr Jamie Freeman discusses how Horizon Discovery engineers cell lines to enable deeper understanding of basic biology of ... including CRISPR-Cas9 and ZFNs, and we have even developed ...

Australian researchers have successfully introduced an improved version of Cas12a gene-editing enzyme in mice.

"This has important implications for basic research ... in the Chagas Disease Vector Rhodnius prolixus by Cas9-Mediated ReMOT Control, The CRISPR Journal (2024). DOI: 10.1089/crispr.

Our group has determined the crystal structure of the complex formed by anti-CRISPR protein AcrIIA4 and sgRNA-bound type II Cas9. We show that AcrIIA4 preferentially ... defines how a lysine-rich ...

Among the most exciting breakthroughs are gene therapy and gene editing, with CRISPR-Cas9 leading the charge. This remarkable tool, inspired by bacteria's natural defenses, acts like precise ...

Using CRISPR/Cas9-activation screen, functional analysis, and engineered zebrafish models, the study aims to uncover the mechanisms by which CRX and OTX2 regulate the retinoic acid signaling pathway ...

For the first time, CRISPR-Cas9 gene editing is used in kissing bugs ... This has important implications for basic research, but it also brings triatomine bugs and Chagas disease into ...

ZUG, Switzerland and BOSTON, Jan. 13, 2025 (GLOBE NEWSWIRE) -- CRISPR Therapeutics (Nasdaq: CRSP), a biopharmaceutical company focused on creating transformative gene-based medicines for serious ...