The Structure, Function, and Mechanisms of Action of Enterovirus …
WEBDec 13, 2020 · In this review, we discuss and summarize the current understanding of the structure, function, and mechanism of the enterovirus 2C proteins, focusing on the key mutations and motifs involved in viral infection, replication, and immune regulation.
Enterovirus A71 Proteins: Structure and Function - PMC
WEBFeb 21, 2018 · Many recent studies have discussed the structure and function of EV-A71 proteins, and the findings reported will definitely aid the development of vaccines and therapeutic approaches. This article reviews the progress in the research on the structure and function of EV-A71 proteins.
Enterovirus - StatPearls - NCBI Bookshelf - National Center for ...
WEBJul 31, 2023 · Structurally, all enteroviruses are small, at 15-30 nm viruses within the Picornaviridae family. The capsids are icosahedral and contain positive-sense single-stranded RNA (+ssRNA) of approximately 7400 nucleotides in length.
The life cycle of non-polio enteroviruses and how to target it
WEBApr 6, 2018 · In this Review, we discuss our current understanding of enterovirus structure, host–receptor interactions, mechanisms of uncoating and the recent discovery of a universal enterovirus host...
Enteroviruses: The role of receptors in viral pathogenesis
WEBJan 1, 2022 · Schematic of enterovirus capsid. A schematic showing how the various enteroviral proteins form subunits, which then make up the icosahedral capsid, highlighting key features such as the canyon. Schematic was generated using Biorender.
Molecular Biology and Classification of Enteroviruses
WEBJan 1, 2012 · Like other picornaviruses, enteroviruses have a simple structure consisting of a small (about 28 nm diameter), icosahedral protein coat made up of 60 copies of 4 proteins (VP1–4), which surrounds a single-stranded, positive-sense RNA genome (Stanway et al. 2004).
Enteroviral proteases: structure, host interactions and ... - PubMed
WEBHere, we discuss the function of the enteroviral proteases in the virus replication cycle and review the current knowledge regarding how these proteases modulate the infected cell in order to favour virus replication, including ways …
Enteroviruses: epidemic potential, challenges and opportunities …
WEBJul 15, 2024 · Enterovirus replication cycle (schematic representation). After receptor attachment and internalization by endocytosis, the genome is uncoated. As positive stranded RNA viruses, enteroviruses utilise host-cell machinery in genome replication – the replication takes place in a replication organelle, which …
Enteroviral proteases: structure, host interactions and …
WEBMay 4, 2016 · These proteases perform the post-translational proteolytic processing of the viral polyprotein, but they also cleave several host-cell proteins in order to promote the production of new virus particles, as well as to evade the …
Schematic overview of the enterovirus life cycle. After binding …
WEBThe life cycle of all enteroviruses ( Figure 1) starts with binding to one or multiple cell surface receptors, resulting in receptor-mediated endocytosis. Enteroviruses can use various endocytic...
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